中国临床药理学杂志

参考文献

[1]STOWER H.Meningeal lymphatics in aging and Alzheimer’s disease[J].Nat Med,2018,24(12):1781．

[2]CALSOLARO V,ANTOGNOLI R,OKOYE C,et al.The use of antipsychotic drugs for treating behavioral symptoms in Alzheimer’s disease[J/OL].Front Pharmacol,2019,10:e1465.2019-12-06[2021-03-30].https://pubmed.ncbi.nlm.nih.go v/31920655/．

[3]ZHAO Y,HOU D,FENG X,et al.Role of ABC transporters in the pathology of Alzheimer's disease[J].Rev Neurosci,2017,28 (2):155-159．

[4]AKRAM A,SCHMEIDLER J,KATSEL P,et al.Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus[J/OL].Brain Res,2010,1318:e167-e177.2010-03-08[2021-02-27].https://pubmed.ncbi.nlm.nih.gov/20079340/．

[5]FAN J,ZHAO R Q,PARRO C,et al.Small molecule inducers of ABCA1 and apo E that act through indirect activation of the LXRpathway[J].J Lipid Res,2018,59(5):830-842．

[6]BEHL T,KAUR I,SEHGAL A,et al.The interplay of ABC transporters in Aβtranslocation and cholesterol metabolism:Implicating their roles in Alzheimer's disease[J].Mol Neurobiol,2021,58(4):1564-1582．

[7]BRUCKMANN S,BRENN A,GRUBE M,et al.Lack of P-glycoprotein results in impairment of removal of beta-amyloid and increased intraparenchymal cerebral amyloid angiopathy after active immunization in a transgenic mouse model of Alzheimer’s disease[J].Curr Alzheimer Res,2017,14(6):656-667．

[8]SHINDE P,VIDYASAGAR N,DHULAP S,et al.Natural products based P-glycoprotein activators for improvedβ-amyloid clearance in Alzheimer's disease:An in silico approach[J].Cent Nerv Syst Agents Med Chem,2015,16(1):50-59．

[9]PAN J,HE R,HUO Q,et al.Brain microvascular endothelial cell derived exosomes potently ameliorate cognitive dysfunction by enhancing the clearance of Aβthrough up-regulation of P-gp in mouse model of AD[J].Neurochem Res,2020,45(9):2161-2172．

[10]HARTZ A M S,ZHONG Y,SHEN A N,et al.Preventing P-gp ubiquitination lowers Aβbrain levels in an Alzheimer's disease mouse model[J/OL].Front Aging Neurosci,2018,10:e186.2018-06-26[2021-02-27].https://pubmed.ncbi.nlm.nih.gov/29997495/．

[11]ZHANG C,QIN H,ZHENG R,et al.A new approach for Alzheimer's disease treatment through P-gp regulation via ibuprofen[J].Pathol Res Pract,2018,214(11):1765-1771．

[12]SHUBBAR M H,PENNY J I.Therapeutic drugs modulate ATP-Binding cassette transporter-mediated transport of amyloid beta(1-42) in brain microvascular endothelial cells[J/OL].Eur JPharmacol,2020,874:e173009.2020-05-05[2021-03-02].https://pubmed.ncbi.nlm.nih.gov/32061744/．

[13]PEREIRA C D,MARTINS F,WILTFANG J,et al.ABC transporters are key players in Alzheimer's disease[J].J Alzheimers Dis,2018,61(2):463-485．

[14]BEHL T,KAUR I,SEHGAL A,et al.The interplay of ABC transporters in Aβtranslocation and cholesterol metabolism:Implicating their roles in Alzheimer's disease[J].Mol Neurobiol,2021,58(4):1564-1582．

[15]DO T M,NOEL-HUDSON M S,RIBES S,et al.ABCG2 and ABCG4 mediated efflux of amyloid-βpeptide 1-40 at the mouse blood-brain barrier[J].J Alzheimers Dis,2012,30(10):155-166．

[16]MICHAKI V,GUIX F X,VENNEKNS K,et al.Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-βproduction by altering Nicastrin maturation and intracellular localization[J].J Biol Chem,2012,287(2):1100-1111．

[17]HU W,LIN X,ZHANG H,et al.ATP binding cassette subfamily a member 2 (ABCA2) expression and methylation are associated with Alzheimer’s disease[J/OL].Med Sci Monit,2017,23:e5851-e5861.2017-12-10[2021-03-02].https://pubmed.ncbi.nlm.nih.gov/29224028/．

[18]JEPSEN W M,DE BOTH M,SINIARD A L,et al.Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1)overexpression reduces APP processing and increases alpha-versus beta-secretase activity,in vitro[J].Biol Open,2021,10 (1):bio054627．

[19]KROHN M,LANGE C,HOFRICHTER J,et al.Cerebral amyloid-βproteostasis is regulated by the membrane transport protein ABCC1in mice[J].J Clin Invest,2011,121(10):3924-3931．

[20]ZOUFAL V,MAIRINGER S,KROHN M,et al.Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21mice with positron emission tomography[J].J Cereb Blood Flow Metab,2020,40(5):954-965．

[21]丁薇，朱丹丹，刘名义，等．熊果酸对Hep G2细胞中有机阴离子转运多肽1B3表达的影响及其机制研究[J]．中国临床药理学杂志，2019,35(19):2351-2355．

[22]DO T M,BEDUSSI B,CHASSEIGNEAUX S,et al.Oatp1a4 and an L-thyroxine-sensitive transporter mediate the mouse bloodbrain barrier transport of Amyloid-βpeptide[J].J Alzheimers Dis,2013,36(3):555-561．

[23]WEN J H,ZHAO M H,LIU L L.Expression of Oatp2 in the brain and liver of Alzheimer disease mouse model[J].ACS Chem Neurosci,2020,11(3):226-227．

[24]TONG H,ZHANG X,MENG X,et al.Amyloid-beta peptide decreases expression and function of glutamate transporters in nervous system cells[J/OL].Int J Biochem Cell Biol,2017,85:e75-e84.2017-02-08[2021-03-20].https://pubmed.ncbi.nlm.nih.gov/28189841/．

[25]HASCUP E R,BRODERICK S O,RUSSELL M K,et al.Diet-induced insulin resistance elevates hippocampal glutamate as well as VGLUT1 and GFAP expression in AβPP/PS1 mice[J].JNeurochem,2019,148(2):219-237．

[26]DU X,LI J,LI M,et al.Research progress on the role of type Ivesicular glutamate transporter (VGLUT1) in nervous system diseases[J/OL].Cell Biosci,2020,10:e26.2020-03-04[2021-03-20].https://pubmed.ncbi.nlm.nih.gov/32158532/．

[27]YU Y,NICCOLI T,REN Z,et al.PICALM rescues glutamatergic neurotransmission,behavioural function and survival in a drosophila model of Aβ42 toxicity[J].Hum Mol Genet,2020,29 (14):2420-2434．

[28]THORAJAK P,PANNANGRONG W,WELBAT J U,et al.Effects of aged garlic extract on cholinergic,glutamatergic and GABAergic systems with regard to cognitive impairment in Aβ-induced rats[J].Nutrients,2017,9(7):686.