中国临床药理学杂志

目的评价红霉素、阿奇霉素序贯疗法与单用阿奇霉素治疗小儿肺炎支原体肺炎的临床疗效。方法入选114例小儿肺炎支原体肺炎,并随机分为2组,每组57例。试验组用红霉素25~30 mg·kg-1每天1次滴注,3⁷ d后改口服阿奇霉素10 mg·kg-1,3 d后停药4 d。对照组口服阿奇霉素10 mg·kg-1每天1次,5 d后停药7 d,再口服阿奇霉素10 mg·kg-1,每天1次,3 d后停药4 d。2组均3周为1个疗程,比较2组患儿的临床疗效、临床症状消失时间、住院时间及不良反应发生率。结果治疗后,试验组的总有效率为96.49%,显著高于对照组的77.19%(P<0.01);试验组退热时间、止咳时间、湿啰音消失时间及住院时间均明显低于对照组(P<0.01);观察组的不良反应发生率为7.02%,对照组为3.51%,差异无统计学意义(P>0.05)。结论红霉素、阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的疗效显著。

Objective To evaluate the clinical efficacy of erythromycin and azithromycin sequential therapy with single azithromycin treatment on pediatric mycoplasma pneumonia.Methods One hundred and fourteen cases of pediatric mycoplasma pneumonia were randomly divided into two groups,with 57 cases in each group.Patients in the treatment group were treated with erythromycin combined with azithromycin,and those in the control group were treated with azithromycin,and the treatment lasted for3 weeks.The data of clinical efficacy,clinical symptoms and hospitalization time of two groups were compared after treatment.Results The total effective rate of the treatment group was 96.49%,significantly higher than that of control group(77.19%)(P < 0.01).The time points that fever,cough and lung rales disappeared and hospitalization time of the treatment group were significantly lower than those of control group(P <0.01).The rate of adverse reactions in the treatment group was 7.02%and 3.51%in control group but without statistical difference(P >0.05).Conclusion Erythromycin combined with azithromycin treatment for pediatric mycoplasma pneumonia is notably effective.